What is Humanized mouse model?

• Mouse models with a human immune system
• Human immune systems are established by engrafting human CD34⁺ hematopoietic stem cells into immunodeficient mice
• These models are applicable for research on the human immune system and immune-related diseases

Procedure for generating humanized mouse models

HIS Humanized Mice

• Production and supply of HIS humanized mice

• Provision of patient-derived xenograft (PDX) humanized mouse models

• A key in vivo POC model for evaluating human immune-targeted therapeutics

• High cost of materials required for humanized mouse production limits commercialization

• Domestic technological limitations hinder full-scale service implementation

Example of Tumor Study Using HIS Humanized Mouse Model

• week 10(20220112)
  No.	hCD45+	% in hCD45+ population
  		CD19 (B cell)	CD3 (T cell)
  1	22.2	84.2	1.2
  2	16.4	89	1.2
  3	16.6	84.3	0.5
  4	11.4	78.8	1.6
  5	19.5	83	0.9
  6	14.4	83.7	0.4

• week 15(20220217)
  No.	hCD45+	% in hCD45+ population
  		CD19 (B cell)	CD3 (T cell)
  1	52.9	77	12.3
  2	48.4	86.7	2.4
  3	40.8	91	0.6
  4	50	87.4	5.3
  5	50.3	90.9	1.4
  6	29.3	92.1	0.8

• week 23(20220415)
  No.	hCD45+	% in hCD45+ population
  		CD19 (B cell)	CD3 (T cell)
  1	14.6	15.5	68.5
  2	21.5	49.4	19.8
  3	81.2	4.7	62.7
  4	22.6	13.6	73.6
  5	16.1	36	40.4
  6	10.4	19.9	42.6

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